1690 Amsterdam – Dictionnaire Universel Antoine Furetiere where we read: ‘”Orvietan” antidote or contrapoison that became famous in Paris distributed by an operator who came from Orvieto’.

1665 Paris – Molière. In the play L’Amour Médecin, the character Sganarelle, in order to cure her daughter, sends Orvietan to buy her daughter after consulting no less than four doctors without having the solution

1680 Geneva – Dictionnaire Francois Pierre Richelet. “Orvietan” a kind of contravene that was called orvietano by an operator from Orvieto, which is a city in Italy.

1685 Frankfurt – Johannes Schröder First official publication of the Orvietan personal formula in the ‘Pharmacopoeia Medico-Chimica

1690 Amsterdam – Dictionnaire Universel Antoine Furetiere where we read: ‘”Orvietan” antidote or contrapoison that became famous in Paris distributed by an operator who came from Orvieto

1697 Parigi – Nicholas Lemery publishes three ways on how to prepare L’Orvietan in his famous Pharmacopoeia Universelle, an indispensable tool for pharmacists of the time.

1760 Stoccarda –Pharmacopoeia printed in Stuttgart in Latin containing the recipe for Orvietanum, confirming its popularity in the German area.

1787 Venezia – Dizionario della lingua Inglese e Italiana Francesco di Niccolò Pezzana: “”Orvietan” s.m. a kind of antidote”.

1788 Parigi – Paris – Baumé, Pharmacopoeia of the famous Master Apothecary of Paris with more recipes from Orvietano.

1821 Milano – Alessandro Manzoni. The writer, in his first version of the Promessi Sposi (The Betrothed), where next to Lucia there was still Fermo, expressly mentions the Orvietan when Donna Prassede, Don Ferranti’s wife, recommends its use.

1821 Londra – Sir Walter Scott. In the novel ‘Kenilworth’, the preparation of the Orvietan by the legendary Wayland Smith is described.

1825 Londra – Sir Walter Scott. In the novel ‘The Talisman’, in the episode where they attempt to assassinate King Richard the Lionheart, it is the king himself who advises one of his slaves, wounded by a poisoned dagger, to take an Orvietan dram.

1848 Torino – Achille Longhi and G.B. Menini Dictionary of the Italian Language: “”Orvietan” s.m. Famous antidote invented and propagated by Girolamo Ferrante of Orvieto.

1893 Parigi – Dr Le Paulmier publishes extensive research on the Contugi family in Paris and collects many documents on Orvietan, leaving many traces for future historical research.

1951 Mondovì – Alberico Benedicenti, an essay on the evolution of pharmacopoeia in Italy and Europe, from the 17th to the 19th century, with a chapter devoted entirely to the Orvietano area, with numerous details of events surrounding the sale of the famous drug.

2000 Roma – Dizionario di alchimia e di chimica farmaceutica antiquaria Fumagalli Marcello: ‘”Orvietan”, a famous opiate antidote invented in the city of Orvieto from which it took its name.».

2004 Modena – Patrizia Catellani and Renzo Console publish the most important historical research on L’Orvietan and, analysing all the formulas of the pharmaceutical treaties, indicate their ‘ideal Orvietan’, a valuable suggestion for the preparation of contemporary formulas

2008 Oxford – David Gentilcore, Study of modern medicine in Italy.

2011 Orvieto – Sandro Bassetti publishes “L’Orvietan. Medicina universale 1504-1828′ historical research on the well-known electuary.

2011 Orvieto – Alberto Satolli presents his historical research on Orvietan ceramics in Orvieto.

2016 Venezia – Sabrina Minuzzi researches therapeutic and medical practices in Venice from the 1500s to the 1800s with the discovery of the Venetian branch of the Orvietan where a woman, Elisabetta Merulla, for the first time obtained a concession to manipulate and produce a drug. 

2016 Milano – Garzanti linguistics: ‘”Orvietan”, a panacea invented, according to tradition, by Ferrante d’Orvieto.».

2019 Orvieto – Laura Calderini, “Le disobbedienti di San Zaccaria”. The author lives and works in Orvieto, where she set the first part of the novel, which then continues in 17th-century Venice, where Orvietan is also the protagonist of a narrated story.